Trypanosome antigenic variation
WebAntigenic variation belongs to the general survival strategy of enhanced phenotypic variation, where a subset of 'contingency' genes of viruses, bacteria and parasites … WebMar 1, 2004 · Antigenic variation is central to the success of African trypanosomes and other eukaryotic, bacterial and viral pathogens. Our understanding of the control and execution of this immune evasion strategy in trypanosomes is incomplete, despite the molecular basis of antigenic variation being first described over 20 years ago. Recent …
Trypanosome antigenic variation
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WebMar 27, 2015 · The protozoan parasite Trypanosoma brucei, a major cause of human and animal Trypanosomiasis, lives extracellularly within its mammalian host, where it is … WebAntigenic variation or antigenic alteration refers to the mechanism by which an infectious agent such as a protozoan, bacterium or virus alters the proteins or carbohydrates on its …
WebOct 10, 2024 · The protozoan parasite Trypanosoma brucei, a causative agent of human and animal trypanosomiasis, lives extracellularly within its host and evades host immunity through antigenic variation of its ... WebJan 29, 2010 · Parasite-intrinsic factors can explain ordered progression of trypanosome antigenic variation. Proceedings of the National Academy of Sciences, USA 104, 8095 – 8100. 0606206104 [pii] 10.1073/pnas.0606206104 CrossRef Google Scholar PubMed
WebNational Center for Biotechnology Information WebDec 22, 2024 · An extreme form of antigenic variation, based around switching the composition of a variant surface glycoprotein (VSG) coat, is exhibited by the African …
WebSep 25, 2024 · Many parasites escape the host immune system by undergoing antigenic variation, a process in which surface antigens are regularly shed and replaced by new ones. Trypanosoma brucei employs multiple sophisticated molecular mechanisms to ensure the expression of a homogeneous VSG coat.
WebA number of mechanisms have been described by which African trypanosomes undergo the genetic switches that differentially activate their variant surface glycoprotein genes (VSGs) and bring about antigenic variation. These mechanisms have been observed mainly in trypanosome lines adapted, by rapid syringe passaging, to laboratory conditions. dynamics version historyWebAntigenic variation is central to the success of African trypanosomes and other eukaryotic, bacterial and viral pathogens. Our understanding of the control and execution of this … dynamics version numbersWebStudies on Variant Surface Glycoproteins (VSGs) and antigenic variation in the African trypanosome, Trypanosoma brucei, have yielded a remarkable range of novel and … cs 1100 georgia techWebFeb 12, 2024 · African trypanosomes (Trypanosoma) are vector-borne haemoparasites that survive in the vertebrate bloodstream through antigenic variation of their Variant Surface Glycoprotein (VSG). Recombination ... cs1100 sophiaWebWe have analyzed antigenic variants with a known lineage and show that there are several telomeres on which variant surface glycoprotein (VSG) genes can be expressed. These telomeres have similar restriction maps 5′ to the barren region. In addition, the same VSG gene was expressed on different telomeres. Some antigenic switches in the lineage were … cs1100s0170WebTrypanosoma brucei has developed the most elaborate capacity for antigenic variation. Trypanosomes branched early during eukaryotic evolution. They are characterized by many aberrations, ranging from the unusual compartmentation of metabolic pathways to the heresy of RNA editing. cs1100xpeWebThe antigenic repertoire of a trypanosome clone or species is so far undetermined and the genetic basis of antigenic variation is unexplored. Structural studies indicate that the … dynamics versionnumber