WebJul 8, 2024 · Large B-cell lymphoma with IRF4 rearrangement (LBCL-IRF4) constitutes a novel provisional entity included in the classification of lymphoid tissue recently proposed … WebIn addition, IRF4-deficient B cells had impaired expression of activation-induced deaminase and lacked class-switch recombination, suggesting an independent function for IRF4 in this process. These results identify IRF4 as a crucial transcriptional 'switch' in the generation of functionally competent plasma cells.
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WebDec 1, 2024 · The overexpression of MUM1 is often activated by IRF4 rearrangement which was mainly reported in multiple myeloma [5] and was first reported in B-cell lymphoma in 2011(2).Immunohistochemical staining of MUM1 was positive in 50%–70% of LBCLs, while the incidence of IRF4 rearrangement in LBCL originating from Waldeyer’s ring is only 8% [6 … WebSep 1, 2024 · Large B-cell lymphoma with IRF4 rearrangement (LBCL-IRF4) constitutes a novel provisional entity included in the classification of lymphoid tissue recently proposed by the WHO in its fourth revised edition.1 LBCL-IRF4 is a rare type of large B-cell lymphomas and accounts for 0.05% of cases. Literature reports it to be more common in children ... phone number for honda dealer
Transcription factor IRF4 controls plasma cell differentiation and ...
WebApr 11, 2024 · A notable characteristic of type 2 immunity is that the initiation of the allergic response requires repeated exposures to the allergen. This contrasts with type 1 immunity, where a single infection is sufficient to drive a full-fledged immune response. One possible reason for this difference is that microbial antigens “replicate ... WebApr 13, 2024 · The family/class of the large B-cell lymphomas (LBCL) in the 5th edition of the World Health Organization (WHO) classification of haematolymphoid tumors (WHO-HAEM5) features only a few major changes as compared to the 4th edition. In most entities, there are only subtle changes, many of them only representing some minor modifications in … WebSep 29, 2024 · In vitro Stimulation of Human B Cells Generated Populations With Distinct IRF4 and Pax5 Expression Levels To evaluate PC differentiation in vitro at the transcription factor level, we next assessed the expression of IRF4 and Pax5. phone number for hood