WebFoxM1 promotes proliferative expansion during HCC development ( 39 – 41 ), with several lines of evidences claiming up-regulated FoxM1 as a marker for aggressive HCC and poor prognosis ( 42, 43 ). FoxM1 inactivation, therefore, leads to inhibition of HCC progression and invasion ( 32, 44, 45 ). WebJul 19, 2012 · Several recent studies reported that FoxM1 was significantly upregulated in human HCC tissues and that its overexpression indicated poor prognosis in HCC patients ( 21–24 ). Conditionally deleted FoxM1 mouse hepatocytes failed to proliferate and were highly resistant to developing HCC in response to diethylnitrosamine ( 25 ).
Regulation of the master regulator FOXM1 in cancer
WebSep 9, 2024 · FOXM1 also has a vital role in the progression of Ras-driven HCC. Specifically, FOXM1 activates CD44 expression and regulates reactive oxygen species … WebApr 8, 2024 · KLF4 plays a role in inhibiting the development of hepatocellular carcinoma (HCC). ... TIMP-1, TIMP-2, FOXM1, CD44 and MSI, exerting a tumor-regulatory effect. Among them, P21, P27, P53 and Cyclin ... nall hollis controversy
FOXM1-induced TYMS upregulation promotes the progression of ...
WebMay 9, 2024 · FOXM1-induced HCC cell proliferation was dependent on elevated KIF4A expression as KIF4A knockdown abolished FOXM1-induced proliferation of HCC cells … WebAug 22, 2012 · FoxM1 induces EMT by activating the protein kinase B/Snai1 pathway, which leads to metastasis in pancreatic cancer and HCC. 5, 6 FoxF1 and FoxQ1 promote EMT and breast cancer metastasis through the inhibition of E-cadherin transcription. 7, 8 In contrast, FoxA1 and FoxA2 antagonize EMT through the transactivation of E-cadherin … WebJan 5, 2024 · FOXM1 (Forkhead box M1) is a key regulator of tumorigenesis. Previous studies demonstrated that FOXM1 … meds taken on empty stomach