WebJul 15, 2024 · Cy/Flu cyclophosphamide and fludarabine. HER2 CAR T cells expand safely after lymphodepletion The Cy/Flu regimen induced grade 4 lymphopenia, with an absolute lymphocyte count of 11–19 cells/mm 3 on the day of HER2 CAR T-cell infusion (day 0). WebOct 1, 2007 · In Cy/Flu/DLI patients, T-cell proliferation was elevated at 14 days after DLI. Although these data suggest that chemotherapy-induced lymphodepletion enhances activation of donor lymphocytes, the toxicity needs to be managed before testing whether better disease control can be achieved.
Tumor response and endogenous immune reactivity after ... - Nature
WebMar 30, 2024 · According to prior therapies and prior adverse reactions to chemotherapy, 12 patients received cyclophosphamide (Cy) (300 mg/m 2 for 5 days) plus fludarabine (Flu) (30 mg/m 2) regimen and 27... WebFeb 16, 2024 · Immune effector cell-associated neurotoxicity syndrome (ICANS) has not occurred. CRS marker elevations were modest (max IL-6: 642.6 pg/mL). The most common AEs were cytopenias, infections, and constitutional symptoms (Gr ≥3 60%, 10%, and 0%), as expected with lymphodepletion. Treatable related ocular AEs were noted in 3 patients. flame wok
Targeted lymphodepletion with a CD45-directed antibody …
WebOct 1, 2007 · In Cy/Flu/DLI patients, T-cell proliferation was elevated at 14 days after DLI. Although these data suggest that chemotherapy-induced lymphodepletion enhances activation of donor lymphocytes, the toxicity needs to be managed before testing whether better disease control can be achieved. WebMay 28, 2024 · Conclusions: ALLO-647/Flu +/- Cy had a tolerable safety profile and produced a deep and durable window of lymphocyte depletion. ALLO-647 exhibited target-mediated drug disposition; clearance increased with higher baseline LC. HD was associated with higher IL15 levels and better CAR T expansion, suggesting dose responses. WebOct 17, 2024 · Specific toxicities associated with lymphodepletion agents Fludarabine (Flu): fevers and neurotoxicity; Cyclophosphamide (Cy): hemorrhagic cystitis, pericarditis, and neurotoxicity; Use of these agents may increase the risk of developing secondary … flame woodfire pizza