WebSep 1, 2006 · Figure 2C shows that H460-pMEP 4-MKP-1 cells treated with CdSO 4 were more resistant to both doses of cisplatin compared with the control H460-pMEP 4 vector cells . Thus, these results indicate that overexpression of MKP-1 plays a critical role in cisplatin resistance in the H460 human lung cancer cell. WebOct 1, 2024 · Similar in CRPC, para-toluenesulfonamide inhibited the Akt/mTOR/p70S6K pathway in NSCLC cell lines NCI-H460 and A549, leading to G1 arrest of the cell cycle and apoptosis. Para-toluenesulfonamide significantly decreased the cholesterol levels of plasma membrane. ... (Figure 7A,B) but not that with paclitaxel or cisplatin (Figure S6 ...
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WebC is-diamminedichloroplatinum(II) (cisplatin) is the most celebrated metal-based chemotherapeutic in the history of modern medicine.The discovery of its anticancer effects was not only opportune [1,2,3], especially during a period when cancer prevention was desperately needed, but also because medical oncology did not yet exist as a clinical … WebNov 5, 2024 · Oroxylin A attenuates hypoxia-induced cisplatin resistance a H460 cells were treated with cisplatin under normoxic (20% O2) or hypoxic (1% O2) condition for 36 h. The cell viability was analyzed ... shucw.com
Metformin enhances the radiosensitizing effect of cisplatin in …
WebDec 16, 2015 · H460 lung cancer cells increased cisplatin sensitivity and showed reduced repair of both . intrastrand and interstrand adducts suggesting that the mechanism of sensitivity is primarily . WebJul 6, 2024 · A2780 and H460 cells were treated with increasing concentrations of cisplatin (Hospira, Australia) for 48 h, collected, washed twice by centrifugation at 900 g for 5 min with FACS buffer (2.5 % FCS, 0.04 % sodium azide in PBS) and incubated with 5 μg/mL chDAB4 or human IgG (Intragram P; as control) for 30 min. Cells were washed and … WebApr 9, 2024 · In vitro cytotoxicity of free cisplatin and G4.0-PAA/aquated cisplatin nano-complex against NCI H460 cells (human lung cancer cells) was evaluated by SRB assay, and their corresponding IC 50 values were calculated from the dose–response curves using non-linear regression analysis. The cells were incubated for 5 h at pH 7.4 in the … shu cream recipe