Cisplatin chemistry

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August undefined, 2024

WebJul 1, 2024 · Cisplatin is one of the best and first metal-based chemotherapeutic drugs (see Fig. 1 for 3D structure of cisplatin) [10], [287]. It is reported that ∼2 billion U.S. dollars of platinum-based anticancer drugs are sold worldwide [6], [7] and nearly about 50% of all patients are treated with cisplatin [8]. WebCisplatin is a platinum-based chemotherapeutic that has long since been effective against a variety of solid-cancers, substantially improving the five-year survival rates for cancer patients. Its use has also historically been limited by its adverse drug reactions, or cisplatin-induced toxicities (CITs). Of these reactions, cisplatin-induced nephrotoxicity (CIN), …

Cancer Drug 49 Times More Potent than Cisplatin

WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 cells, either induced by cisplatin or by UV light, can lead to further apoptotic death in … WebCisplatin: chemistry, distribution and biotransformation Authors D F Long , A J Repta PMID: 7016212 DOI: 10.1002/bdd.2510020102 Abstract A review of the use of cisplatin … lit-sphere とは

Cisplatin - The Penicillin of Cancer

WebSep 15, 2024 · Cisplatin is the prototype platinum coordination complex classified as an alkylating agent and used intravenously in the treatment of several forms of cancer. … WebJan 28, 2024 · In this study, we sought to provide a comprehensive review of the current state of the science highlighting the use of cisplatin in cancer therapy, with a special emphasis on its molecular mechanisms of action, and treatment modalities including the combination therapy with natural products. WebCisplatin is a tiny little drug molecule that contains a platinum ion in the middle of a flat square with two chloride ions and two ammonia molecules making up the corners. … lits physaro

Cisplatin 4. Electrochemistry - Chemistry LibreTexts

Cisplatin : chemistry and biochemistry of a leading anticancer drug …

WebSep 30, 2024 · Cisplatin resistance in tumor cells is known mainly due to the reduced accumulation of platinum ions by efflux, detoxification by intracellular GSH, and nucleotide excision repair machinery-mediated nuclear DNA repair. WebIntroduction: Cisplatin has been indicated for several malignancies all over the world for many years. Increasing patient tolerance for high dose of chemotherapeutics and reducing side effects has been granted by drug encapsulated liposomal systems. lits picots decathlonWebOne of the first known coordination compounds was Peyrone’s Chloride (also known as cis-diamminedichloroplatinum (II), or cis-DDP), first reported in 1845. This compound was not fully understood until 1893, when Alfred Werner deduced its structure and described cis-DDP and its trans isomer in a landmark paper. lits picots

"WebCisplatin, a platinum analogue, is an alkylating agent used in combination with other agents to treat a variety of solid malignancies, including lung cancer, head and neck cancer, … " - Cisplatin chemistry

Cisplatin chemistry

Anticancer Drugs (7.7.5) AQA A Level Chemistry Revision Notes …

WebJan 9, 2024 · Cancer Drug 49 Times More Potent than Cisplatin ... business news WebJun 10, 1999 · Medicinal bioinorganic chemistry - the role of metal compounds in medicine - has received an enormous boost from cisplatin, and so has bioinorganic chemistry as a whole. There is hardly a better example than cisplatin to demonstrate what bioinorganic chemistry is all about: The marriage between classic inorganic (coordination) chemistry …

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WebOct 5, 2014 · Cisplatin, cisplatinum, or cis-diamminedichloroplatinum (II), is a well-known chemotherapeutic drug. It has been used for treatment of numerous human cancers including bladder, head and neck, lung, ovarian, and testicular cancers. It is effective against various types of cancers, including carcinoma … WebCisplatin coordinates to DNA mainly through certain nitrogen atoms of the DNA base pairs; these nitrogen atoms (specifically, the N7 atoms of purines) are free to coordinate to cisplatin because they do not form hydrogen bonds with any other …

WebConspectusSince its discovery in 1965, the inorganic drug cisplatin has become a mainstay of cancer therapies and has inspired many platinum (Pt)-based compounds to solve … WebFeb 1, 2014 · Journal of Computational and Theoretical Nanoscience February 1, 2014. Behavior of one and two Cisplatin (Cp) molecules confined in (8, 0), (9, 0), (10, 0), (11, 0), (12, 0) (14, 0) and (9, 9) capped and opened single-walled carbon nanotubes (CNTs) is studied by means of ab-initio calculations. Optimized geometry of inclusion complexes …

WebApr 15, 2024 · The treatment was well tolerated only he developed grade 2 mucositis and weight loss associated with cisplatin [ duration of treatment to reactions onset not stated … WebCisplatin / chemistry Cisplatin / metabolism* Colonic Neoplasms / metabolism* Colonic Neoplasms / pathology Copper / metabolism Copper / pharmacokinetics Copper Transporter 1 Dose-Response Relationship, Drug Homeostasis Humans Platinum / metabolism Platinum / pharmacokinetics Structure-Activity Relationship Substances Cation Transport Proteins

WebIn water, the antineoplastic drug cisplatin, cis- [PtCl2 (NH3)2] (1) hydrolyses slowly to the aqua complexes cis- [Pt (NH3)2Cl (H2O)]+ (2) and, to a small extent, cis- [Pt (NH3)2 (H2O)2]2+ (3), which are thought to play an important role in the metabolism of cisplatin.

WebIn the 1960s the drug cis-platin was discovered, which has been extremely effective in treating a number of different types cancer such as testicular, ovarian, cervical, breast, lung and brain cancer. Cancer cells grow and replicate much faster than normal cells. Cis-platin is a square planar molecule that has a geometric isomer with the side ... lits picachuCisplatin is a chemotherapy medication used to treat a number of cancers. These include testicular cancer, ovarian cancer, cervical cancer, bladder cancer, head and neck cancer, esophageal cancer, lung cancer, mesothelioma, brain tumors and neuroblastoma. It is given by injection into a vein. Common side effects include bone marrow suppression, hearing problems, incl… lits plateformeWebCisplatin Cl2H6N2Pt CID 5460033 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity … lit spiral tree setWebThe shape of the cisplatin molecule is square and flat. Its covalent bonds readily exchange with other ligands, including even water. In the aqueous environment of the body, the … lits playmobilWeb2 days ago · One of the main problems in chemotherapy using platinum drugs as anticancer agents is the resistance phenomenon. Synthesizing and evaluating valid alternative compounds is challenging. This review focuses on the last two years of progress in the studies of platinum (II)- and platinum (IV)-based anticancer complexes. In particular, the … lits plateformes king-sizeWebDec 15, 2015 · This strategy was successful in delaying cis-diammineplatinum(II) dichloride (cisplatin, CDDP) leakage and averting spontaneous release under physiological conditions. Nevertheless, our carbon nanobottles were far from being “smart” in achieving controlled release of cargo molecules only in response to specific trigger. litspring.comWebThe antitumor effects of platinum(IV) complexes, considered prodrugs for cisplatin, are believed to be due to biological reduction of Pt(IV) to Pt(II), with the reduction products binding to DNA and other cellular targets. In this work we used pBR322 DNA to capture the products of reduction of oxopl … Pt(IV) complexes as prodrugs for cisplatin lit springboard courses