WebSubsequently, we demonstrated that over-expression of circTCF25 could down-regulate miR-103a-3p and miR-107, increase CDK6 expression, and promote proliferation and … Weboverexpression of circTCF25 reduced the levels of miR-206 in os-teosarcoma cells, where transfection of miR-206 mimic abrogated circTCF25-induced pro-tumorigenic phenotypes and the associ-ated protein expression. In this regard, the MEK/ERK and AKT/ mTOR pathways were found to be the downstream pathways in-hibited by miR-206.78 3.1.2 …
CircTCF25 serves as a sponge for miR‐206 to support …
WebJan 15, 2024 · WST-8 assay. Cells at a density of 5.0 × 10 4 cells/mL were plated in a 96-well plate and divided into five groups: miR-21-5p group (miR-2-5p over-expression), NC group (infected with negative control lentiviral vector), control group (no infection), sh-Tiam1 group (infected with lentiviral vector expressing short hairpin (sh)-Tiam1), and sh … WebJun 7, 2024 · Circular RNAs (circRNAs) are novel members of the noncoding RNA family. Their characteristic covalent closed-loop structure endows circRNAs that are much more stable than the corresponding linear transcript. circRNAs are ubiquitous in eukaryotic cells, and their functions are diverse and include adsorbing microRNAs (miRNAs; acting as … binary code shirt
An update on the roles of circular RNAs in osteosarcoma
WebFeb 13, 2024 · Our study aimed to unravel whether circTCF25 dictates cellular activities of osteosarcoma cells and address the possible mechanisms associated with microRNA (miR). circTCF25 and miR‐206 in clinical specimens from 25 patients suffering from osteosarcoma were quantified by quantitative reverse transcription‐polymerase chain reaction … WebAug 12, 2024 · Overexpression of circTCF25 can down-regulate the activity of miR-103a-3p and miR-107, increase the expression of CDK6, and promote the proliferation and migration of bladder cancer cells. Huang et al. found nine circRNAs with miRNA-binding sites. Because these target genes are involved in the development and progression of cancer … WebAug 3, 2016 · The circTCF25 promotes proliferation and migration of bladder cancer cells via circTCF25-miR-103a-3p/miR-107-CDK6 pathway. ( A ) The sketch of structure of … binary code programming